Daisy : Suunnitelma kukaksi koottavasta kahviastiastosta

Opinnäytetyön tavoitteena oli suunnitella kahdeksan hengen kahviastiasto ja valmistaa siitä protoyyppi. Tekijän tarkoituksena oli kehittää myös omaa ammatillista osaamista ja perehtyä työn ohella tuotesuunnitteluun. Lähtökohdan työlle antoi aiemmin vuonna 2007 valmistettu Lumme-astiasto, minkä pohjalta tekijä halusi suunnitella uuden kahviastiaston. Lumme-astiaston ideana oli koota astiat tarjottimen päälle niin, että kokonaisuus näyttäisi lumpeenkukalta. Samaa ideaa apuna käyttäen myös Daisy-kahviastiasto suunniteltiin näyttämään kukalta. Opinnäytetyön tarkoituksena oli suunnitella ammattimaisempi ja toimivampi kahviastiasto, jonka pystyisi suunnittelun pohjalta valmistamaan konkreettiseksi opinnäytetyön ulkopuolella. Daisy-astiaston suunnittelussa huomioitiin erinäisiä tärkeitä seikkoja kuten käytännöllisyyttä, käyttäjiä, esteettisyyttä, valmistusta, materiaaleja sekä astiaston jatkokehittelyä. Ennen varsinaista suunnittelua ja sen aikana tutustuttiin vastaavanlaisiin opinnäytetöihin, joissa pääpaino oli tuotteen suunnittelu. Daisy-astioiden mallien ideointi alkoi tutustumalla tavaratalojen astiaosastoihin. Suunnittelun avuksi näiden pohjalta mietittiin olemassa olevien astioiden hyviä ja huonoja puolia. Tämän jälkeen suunnittelu eteni luonnosten ja tiedonhaun kautta astiaston lopullisen ulkoasun mallintamiseen. Daisy-astiaston suunnittelussa käytettiin enimmäkseen Rhinoceros 3D-mallinnusohjelmaa. Opinnäytetyön yhteistyökumppanina toimi freelancer ja teollinen muotoilija Pekka Laasanen. Yhteistyökumppanin roolina oli antaa palautetta suunnittelusta ja keskustella astiastoon liittyvistä ratkaisuista. Lisäksi yhteistyökumppani auttoi hieman 3D-mallintamisessa ja tarkisti lopuksi, onko 3D-tiedosto valmis pikavalmistettavaksi. Raportoinnin tarkoituksena oli selvittää suunnittelun eri vaiheita ja tarkastella, mitä tuotesuunnittelu yleensä on. Raportti sisältää tarkempaa tietoa myös yhteistyökumppanista. Lopuksi pohditaan ja arvioidaan työn kulkua, suunnittelun lopputulosta ja tavoitteiden saavuttamista.The aim of the final project with thesis was to design coffee tableware for eight people and produce a prototype of it. The author's purpose was also to develop her own professional skills and to study industrial design beside the work. The starting point for the work was Lumme tableware which was made in 2007. Basing on it the author wanted to design new tableware. The idea of Lumme was to join the dishes together on a tray so that the whole tableware would look like a waterlily. Using the same idea, Daisy coffee tableware was designed to resemble a flower. The purpose of the final work was to design more professional and effective coffee tableware which could be produced outside the thesis. Practicality, users, aesthetics, manufacturing, materials and further development were important things when designing Daisy tableware. Before the actual working and during it the author studied similar theses where the main focus was on product design. The ideation of Daisy dishes began by exploring the sets of dishes at department stores. The advantages and disadvantages of the found sets of dishes were contemplated as the help of designing. The designing proceeds through information search and sketching into 3D modeling of the final tableware. The author mostly used Rhinoceros 3D modeling program. The partner was a freelancer and an industrial designer Pekka Laasanen. The partner's role in this project was to give feedback of the design and discuss its solutions in regard to the tableware. In addition, the partner helped in 3D modeling and finally checked whether the 3D file was ready to be produced at a quick machine. The report presents the stages of the design process and discusses what industrial design means. The report also contains detailed information about the partner. In the end the student evaluates her designing process, the result and how she achieved her goals

Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma

PurposeThe two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 (α1-antitrypsin) is a serine protease inhibitor, which plays a role in the tumorigenesis of various cancer types. The aim of the study was to evaluate the expressions of Serpin A1 in LS, premalignant vulvar lesions, and vSCC using immunohistochemistry (IHC) and serum analysis, and to compare Serpin A1 stainings to the tumor markers p53 and p16.MethodsIn total, 120 samples from 74 patients were studied with IHC for Serpin A1, p53 and p16: 18 normal vulvar skin, 53 LS, 9 premalignant vulvar lesions (dVIN/HSIL) and 40 vSCC samples. Serum concentrations of Serpin A1 were analyzed from 30 LS, 44 vSCC and 10 control patients. Expressions were compared to clinical data.ResultsTumor cell-specific Serpin A1 overexpression was detected in 88% of vSCC samples, independent of the etiology. The intensity of Serpin A1 expression was significantly higher in vSCC than in healthy vulvar skin, LS, or premalignant vulvar lesions. Serpin A1 showed an association with p53 positivity. No difference in overall survival was found between Serpin A1-, p53-, or p16-positive vSCC patients. Serum concentrations of Serpin A1 were equal in the LS, vSCC, and control groups.ConclusionTumor cell-specific Serpin A1 overexpression is a potential biomarker in vSCC.</div

Observation of Exclusive Gamma Gamma Production in p pbar Collisions at sqrt{s}=1.96 TeV

We have observed exclusive \gamma\gamma production in proton-antiproton collisions at \sqrt{s}=1.96 TeV, using data from 1.11 \pm 0.07 fb^{-1} integrated luminosity taken by the Run II Collider Detector at Fermilab. We selected events with two electromagnetic showers, each with transverse energy E_T > 2.5 GeV and pseudorapidity |\eta| < 1.0, with no other particles detected in -7.4 < \eta < +7.4. The two showers have similar E_T and azimuthal angle separation \Delta\phi \sim \pi; 34 events have two charged particle tracks, consistent with the QED process p \bar{p} to p + e^+e^- + \bar{p} by two-photon exchange, while 43 events have no charged tracks. The number of these events that are exclusive \pi^0\pi^0 is consistent with zero and is < 15 at 95% C.L. The cross section for p\bar{p} to p+\gamma\gamma+\bar{p} with |\eta(\gamma)| < 1.0 and E_T(\gamma) > 2.5$ GeV is 2.48^{+0.40}_{-0.35}(stat)^{+0.40}_{-0.51}(syst) pb.Comment: 7 pages, 4 figure

Search for Third Generation Vector Leptoquarks in p anti-p Collisions at sqrt(s) = 1.96 TeV

We describe a search for a third generation vector leptoquark (VLQ3) that decays to a b quark and tau lepton using the CDF II detector and 322 pb^(-1) of integrated luminosity from the Fermilab Tevatron. Vector leptoquarks have been proposed in many extensions of the standard model (SM). Observing a number of events in agreement with SM expectations, assuming Yang-Mills (minimal) couplings, we obtain the most stringent upper limit on the VLQ3 pair production cross section of 344 fb (493 fb) and lower limit on the VLQ3 mass of 317 GeV/c^2 (251 GeV/c^2) at 95% C.L.Comment: 7 pages, 2 figures, submitted to PR

Measurement of the t-channel single top quark production cross section in pp collisions at √s =7 TeV

Peer reviewe

Calibration of the CMS Drift Tube Chambers and Measurement of the Drift Velocity with Cosmic Rays

Peer reviewe

Search for microscopic black holes in pp collisions at √s̅ = 7 TeV

Peer reviewe

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run

Peer reviewe

Search for exclusive Z boson production and observation of high mass ppbar->gammagamma->p+ll+pbar events in ppbar collisions at sqrt(s) = 1.96 TeV

submitted to Phys. Rev. LettWe present a search for exclusive Z boson production in proton-antiproton collisions at sqrt(s) = 1.96 TeV, using the CDF II detector at Fermilab. We observe no exclusive Z->ll candidates and place the first upper limit on the exclusive Z cross section in hadron collisions, sigma(exclu) gammagamma->p+ll+pbar, and measure the cross section for M(ll) > 40 GeV/c2 and |eta(l)|This Letter presents a search for exclusive Z boson production in proton-antiproton collisions at √s=1.96  TeV, using the CDF II detector. No exclusive Z→l+l- candidates are observed and the first upper limit on the exclusive Z cross section in hadron collisions is found to be σexcl(Z)40  GeV/c2 and |ηl|<4 is found to be σ=0.24-0.10+0.13  pb, which is consistent with the standard model prediction.Peer reviewe